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TECHNOLOGIES
Our focus is on patent-protected technology
platforms built upon fundamental research that
promise to disrupt the existing chemical and
pharmaceutical industries.
Ultrahigh-throughput
Small Molecule Drug Discovery using
Computational Biophysics, Artificial
Intelligence, and DNA Encoded Libraries
Patents
- Methods for the design of mechanism-based sirtuin activating compounds.US Patent 11,118,211 B2 (2021)
- Methods for the design of mechanism-based sirtuin activating compounds.
US Patent 11,459,597 (2022)
- Methods for the design of nonallosteric sirtuin activating compounds.
US patent application 2022/0002778 A1 (2021)
- Sirtuin modulating compounds and applications thereof.
US patent application 18/090,953 (2022)
Licensees: CCM Protein Upregulation, Inc.
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Passively
and Actively Targeted Drug Delivery using
Computational Biophysics, Nanotechnology, and
Phage Display
Patents
- Amphiphilic polyamino acid block copolymers and nanoparticles thereof for drug delivery applications.EP patent application 22305766.2 – 1102, Filed 2022
- New EGFRvIII-binding peptides, conjugates and uses thereof.
European patent application B77140EP; International patent application PCT/EP2022/087500, Filed 2022
- Compositions and methods for silencing of KRAS.International patent application PCT/US2022/047291, Filed 2022
Licensees: CCM Nanothera Sciences; CCM RAS Sciences,
Inc.
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Ultrahigh-throughput
Enzyme Engineering using Computational Biophysics,
Artificial Intelligence, and Microfluidic Droplet
Based Selection
Patents
- System and methods
for determination of temperature cycling
protocols for polymerase chain reactions.
US Patent 10,861,586 B2 (2020)
- System and methods
for determination of temperature cycling
protocols for polymerase chain reactions.
EP Patent 3,000,366 B1 (2020)
- System and methods
for determination of temperature cycling
protocols for polymerase chain reactions:
optimally controlled PCR. US patent
application 2019/0182944 A1, Filed 2019
- System for
determination of temperature cycling protocols
for polymerase chain reactions: polymerase
extension. US patent application
2019/0279739 A1, Filed 2019
- System for
determination of temperature cycling protocols
for polymerase chain reactions:
oligonucleotide annealing. US patent
application 2019/0270189245, Filed 2019
- System for
determination of temperature cycling protocols
for polymerase chain reactions: DNA melting.
US patent application 2019/0295686 A1, Filed
2019
- Polymerases for
mixed aqueous-organic media and uses thereof,
International patent application
PCT/US2022/011076. Filed 2022
- Compositions and
methods for enhancing PCR and other
polynucleotide amplification reactions. US
Patent 6,949,368 (2005)
- Compositions and
methods for enhancing polynucleotide
amplification reactions. US Patent
7,276,357 (2007)
- Chemical PCR:
Compositions and methods for enhancing
polynucleotide amplification reactions. US
Patent 7,772,383 (2010)
Licensees: Celera Diagnostics, Quest Diagnostics,
Abbott Laboratories, New England Biolabs, Toyobo,
Sekisui Diagnostics, CCM 5Prime Sciences, Inc.
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